Dr.
Mario

Dr. Mario[a] (stylized as DR. MARIO) is a 1990 action puzzle video game produced by Gunpei Yokoi and designed by Takahiro Harada. Nintendo developed and published the game for the Nintendo Entertainment System and Game Boy consoles. The game's soundtrack was composed by Hirokazu Tanaka.

A falling block puzzle game, the player's objective is to destroy the viruses populating the on-screen playing field by using colored vitamin capsules that are tossed into the field by Mario, who assumes the role of a doctor. The player manipulates the capsules as they fall, with the goal being to align similar colors which removes the viruses. The player progresses through the game by eliminating all the viruses on the screen in each level.

A pill was originally defined as a small, round, solid pharmaceutical oral dosage form of medication. Today, pills include tablets, capsules, and variants thereof like caplets — essentially, any solid form of medication colloquially falls into the pill category.

An early example of pills came from Ancient Rome. They were made of the zinc carbonates hydrozincite and smithsonite. The pills were used for sore eyes, and were found aboard a Roman ship Relitto del Pozzino which wrecked in 140 BC. However, these tablets were meant to be pressed on the eyes, not swallowed.

A thumb signal, usually described as a thumbs-up or thumbs-down, is a common hand gesture achieved by a closed fist held with the thumb extended upward or downward in approval or disapproval, respectively. These gestures have become metaphors in English: "The audience gave the movie the thumbs-up" means that the audience approved of the movie, regardless of whether the gesture was actually made.

Many keyboard emoticons utilize the shapes of lowercase "b" and "d" to represent a thumbs-up sign. Simple versions incorporate a dash for the wrist: -b (right hand) and d- (left hand). Many Japanese kaomoji icons place the thumbs beside a face constructed from punctuation marks, such as d(＾＾)ｂ or b(~_^)d. Various instant messaging services use (y) and (n) as a shortcut for thumbs up and thumbs down emoji.